caret, data.table, dtw, dynlm, meboot, Quandl, Rfast, rgl,
stringr, tdigest, zoo

caret, data.table, dtw, dynlm, meboot, Quandl, Rfast, rgl,
stringr, tdigest, tseries, zoo

c(
person("Fred", "Viole", role=c("aut","cre"), email="ovvo.financial.systems@gmail.com"),
person("Roberto", "Spadim", role=c("ctb"))
)
caret, data.table, dtw, dynlm, meboot, MESS, Quandl, Rcpp,
RcppParallel, RcppThread, Rfast, rgl, stringr, tseries, zoo
Fred Viole [aut, cre],
Roberto Spadim [ctb]

caret, data.table, dtw, dynlm, meboot, MESS, Quandl, Rcpp,
RcppParallel, Rfast, rgl, stringr, tseries, zoo

caret, data.table, meboot, MESS, quantmod, Rcpp, RcppParallel,
Rfast, rgl, stringr, xts, zoo

caret, data.table, dynlm, meboot, MESS, quantmod, Rcpp,
RcppParallel, Rfast, rgl, stringr, xts, zoo

caret, data.table, meboot, quantmod, Rcpp, RcppParallel,
Rfast, rgl, stringr, xts, zoo

Calculate Design Parameters for Biomarker Validation Studies
Helps a clinical trial team  discuss
the clinical goals  of a well-defined biomarker with a diagnostic,
staging, prognostic, or predictive purpose.  From this discussion will
come a statistical plan for a (non-randomized) validation trial.
Both prospective and retrospective trials are supported. In a specific
focused discussion, investigators should determine the range of
"discomfort" for the NNT, number needed to treat.  The meaning of
the discomfort range, [NNTlower, NNTupper], is that within this range
most physicians would feel discomfort either in treating or withholding
treatment. A pair of NNT values bracketing that range, NNTpos and NNTneg,
become the targets of the study's design.  If the trial can demonstrate
that a positive biomarker test yields an NNT less than NNTlower,
and that a negative biomarker test yields an NNT less than NNTlower,
then the biomarker may be useful for patients. A highlight of the package
is visualization of a "contra-Bayes" theorem, which produces criteria for
retrospective case-controls studies.
aaa.R ifVerboseCat.R sesp-pv-NNT.R achievable.se.sp.R
binom.confint.R NNTintervals.R run.R