Bayesian Logistic Regression for Oncology Dose-Escalation Trials
Bayesian logistic regression model with optional
EXchangeability-NonEXchangeability parameter modelling for flexible
borrowing from historical or concurrent data-sources. The safety model
can guide dose-escalation decisions for adaptive oncology Phase I
dose-escalation trials which involve an arbitrary number of
drugs. Please refer to Neuenschwander et al. (2008)
<doi:10.1002/sim.3230> and Neuenschwander et al. (2016)
<doi:10.1080/19466315.2016.1174149> for details on the methodology.
c(person("Novartis", "Pharma AG", role = "cph")
,person("Sebastian", "Weber", email="sebastian.weber@novartis.com", role=c("aut", "cre"))
,person("Andrew", "Bean", email="andrew.bean@novartis.com", role="aut")
,person("Trustees of", "Columbia University", role="cph", comment="src/init.cpp, tools/make_cc.R, R/stanmodels.R, src/Makevars, src/Makevars.win")
)
assertthat, checkmate, Formula, rstan (>= 2.18.1), rstantools
(>= 1.4.0), bayesplot (>= 1.4.0), ggplot2 (>= 2.2.1), dplyr (>=
0.7.1), tibble, tidyr, abind, RBesT
rmarkdown, knitr, testthat (>= 2.0.0), mvtnorm, tidybayes
GNU make, pandoc (>= 1.12.3), pandoc-citeproc
Novartis Pharma AG [cph],
Sebastian Weber [aut, cre],
Andrew Bean [aut],
Trustees of Columbia University [cph] (src/init.cpp, tools/make_cc.R,
R/stanmodels.R, src/Makevars, src/Makevars.win)

c(person("Novartis", "Pharma AG", role = "cph")
,person("Sebastian", "Weber", email="sebastian.weber@novartis.com", role=c("aut", "cre"))
,person("Andrew", "Bean", email="andrew.bean@novartis.com", role="aut")
,person("Lukas A.", "Widmer", email="lukas_andreas.widmer@novartis.com", role="aut")
,person("Trustees of", "Columbia University", role="cph", comment="src/init.cpp, tools/make_cc.R, R/stanmodels.R, src/Makevars, src/Makevars.win")
)
assertthat (>= 0.2.1), checkmate, Formula, rstan (>= 2.18.1),
rstantools (>= 2.0.0), bayesplot (>= 1.4.0), ggplot2 (>=
2.2.1), dplyr (>= 0.8.0), tibble, tidyr, abind, RBesT
rmarkdown, knitr, testthat (>= 2.0.0), mvtnorm
Novartis Pharma AG [cph],
Sebastian Weber [aut, cre],
Andrew Bean [aut],
Lukas A. Widmer [aut],
Trustees of Columbia University [cph] (src/init.cpp, tools/make_cc.R,
R/stanmodels.R, src/Makevars, src/Makevars.win)