MASS, mvtnorm, nlme, dplyr, codetools, stats, utils
Optimal experimental designs for both population and individual
studies based on nonlinear mixed-effect models. Often this is based on a
computation of the Fisher Information Matrix (FIM). This package was developed
for pharmacometric problems, and examples and predefined models are available
for these types of systems.

ggplot2, MASS, mvtnorm, dplyr, codetools, stats, utils
testthat, Hmisc, nlme, GA, deSolve, shiny, rhandsontable,
knitr, rmarkdown
Optimal experimental designs for both population and individual
studies based on nonlinear mixed-effect models. Often this is based on a
computation of the Fisher Information Matrix. This package was developed
for pharmacometric problems, and examples and predefined models are available
for these types of systems.

ggplot2, MASS, mvtnorm, dplyr, codetools, stats, utils,
magrittr, boot, purrr, stringr, tibble, tidyr
testthat, Hmisc, nlme, GA, deSolve, Rcpp, shiny,
rhandsontable, knitr, rmarkdown, gridExtra, covr
c(
person("Andrew C.","Hooker", email="andrew.hooker@farmbio.uu.se", role=c("aut","cre","trl","cph")),
person("Marco","Foracchia", role="aut", comment="O-Matrix version"),
person("Eric","Stroemberg", role="ctb", comment="MATLAB version"),
person("Martin","Fink", role="ctb", comment="Streamlining code, added functionality, vignettes"),
person("Giulia","Lestini", role="ctb", comment="Streamlining code, added functionality, vignettes"),
person("Sebastian","Ueckert", role="aut", comment="MATLAB version"),
person("Joakim", "Nyberg", role="aut", comment="MATLAB version")
)
Optimal experimental designs for both population and individual
studies based on nonlinear mixed-effect models. Often this is based on a
computation of the Fisher Information Matrix. This package was developed
for pharmacometric problems, and examples and predefined models are available
for these types of systems. The methods are described in Nyberg et al.
(2012) <doi:10.1016/j.cmpb.2012.05.005>, and Foracchia et al. (2004)
<doi:10.1016/S0169-2607(03)00073-7>.
Andrew C. Hooker [aut, cre, trl, cph],
Marco Foracchia [aut] (O-Matrix version),
Eric Stroemberg [ctb] (MATLAB version),
Martin Fink [ctb] (Streamlining code, added functionality, vignettes),
Giulia Lestini [ctb] (Streamlining code, added functionality,
vignettes),
Sebastian Ueckert [aut] (MATLAB version),
Joakim Nyberg [aut] (MATLAB version)