A Machine Learning Tool for Genetic Association Studies
Portable, scalable and highly computationally efficient tool for genetic association studies."VariantScan" provides a set of machine learning methods (Linear, Local Polynomial Regression Fitting and Generalized Additive Model with Local Polynomial Smoothing)
for genetic association studies that test for disease or trait association with genetic variants
(biomarkers, e.g.,genomic (genetic loci), transcriptomic (gene expressions), epigenomic (methylations), proteomic (proteins), metabolomic (metabolites)).
It is particularly useful when local associations and complex nonlinear associations exist.
c(person("Xinghu", "Qin", role=c("aut", "cre", "cph"), email="qin.xinghu@163.com", comment=c(ORCID="0000-0003-2351-3610")),person("Tianzi", "Liu", role=c("aut"), email="liutz@big.ac.cn"),person("Peilin", "Jia", role=c("aut"), email="pjia@big.ac.cn"))
Xinghu Qin [aut, cre, cph] (<https://orcid.org/0000-0003-2351-3610>),
Tianzi Liu [aut],
Peilin Jia [aut]

Variance Dispersion and Fraction of Design Space Plots
This package creates variance dispersion graphs (VDGs) and fraction of design space (FDS) plots for response surface designs in spherical or cuboidal regions.

This package creates variance dispersion graphs (VDGs), fraction of design space (FDS) plots for second-order model designs in spherical or cuboidal regions, and also generates the central composite designs, factorial designs.

Variance Dispersion, Fraction of Design Space Plots, and
Designs.
This package creates variance dispersion graphs (VDGs), fraction of design space (FDS) plots for second-order model designs in spherical or cuboidal regions. This package also generates the central composite designs, factorial designs, Hartley's small composite designs, Roquemore's hybrid designs, Plackett-Burman composite designs, Doehlert's uniform shell designs, Box-Behnken Designs, and exact A- and D-optimal designs.

Variance Dispersion, Fraction of Design Space Plots, Designs,
and Contour Plots
This package creates variance dispersion graphs (VDGs), fraction of design space (FDS) plots, and contour of SPVs for second-order model designs in spherical or cuboidal regions. The package also generates some response surface designs.