A Modular Framework for Statistical Simulations in R
c(person("Avi", "Kenny", email = "avi.kenny@gmail.com", role = c("aut", "cre")),
person("Charles", "Wolock", email = "cwolock@uw.edu", role = "aut"))

Simulation of Evolution of Enzyme Under Constraints
c(person("Charlotte", "Coton", role = c("aut", "cre"), email = "charlotte.coton@universite-paris-saclay.fr", comment=c(ORCID="0000-0002-5371-0327")),
person("Gregoire", "Talbot", role = c("aut")),
person("Maud", "Le Louarn", role = c("aut")),
person("Christine", "Dillmann", role = c("aut", "ths"), email = "christine.dillmann@inrae.fr", comment=c(ORCID="0000-0002-9025-341X")),
person("Dominique", "de Vienne", role = c("aut", "ths"), email = "dominique.de-vienne@inrae.fr", comment=c(ORCID="0000-0003-3395-7901")))
Charlotte Coton [aut, cre] (<https://orcid.org/0000-0002-5371-0327>),
Gregoire Talbot [aut],
Maud Le Louarn [aut],
Christine Dillmann [aut, ths] (<https://orcid.org/0000-0002-9025-341X>),
Dominique de Vienne [aut, ths]
(<https://orcid.org/0000-0003-3395-7901>)
Simulate the evolution of enzyme concentrations under selection for increased flux in a metabolic pathway, with cellular constraints.
Create graphics for the simulation results.
Compute evolutionary equilibrium and Range of Neutral Variations of enzyme concentrations.
This package is part of "Coton, C., Talbot, G., Le Louarn, M., Dillmann, C., de Vienne, D. (2021) <bioRxiv:10.1101/2021.05.04.442631>".
stats, rgl, ade4, graphics, grDevices, RColorBrewer,
scatterplot3d

Simulate the evolution of enzyme concentrations under selection for increased flux in a metabolic pathway, with cellular constraints.
Create graphics for the simulation results.
Compute evolutionary equilibrium and Range of Neutral Variations of enzyme concentrations.
This package is part of "Coton, C., Talbot, G., Le Louarn, M., Dillmann, C., de Vienne, D. (2021) <bioRxiv:10.1101/2021.05.04.442631>".
Version 2.0.0 and more takes account of regulation groups, and is part of a second article "Coton, C., Dillmann, C., de Vienne, D. (in progress)".