c(person("Toby", "Kenney", email = "tkenney@mathstat.dal.ca", role = c("aut", "cre")),person("Tianshu", "Huang", email = "", role = c("aut")))
For a multivariate dataset with independent Poisson measurement error, calculates principal components of transformed latent Poisson means. T. Kenney, T. Huang, H. Gu (2019) <arXiv:1904.11745>.
Toby Kenney [aut, cre],
Tianshu Huang [aut]

Significance analysis of sequencing data based on a Poisson log
linear model
This package implements a method for normalization,
testing, and false discovery rate estimation for RNA-sequencing
data. The description of the method is in Li J, Witten DM,
Johnstone I, Tibshirani R (2011). Normalization, testing, and
false discovery rate estimation for RNA-sequencing data.
Submitted. Briefly speaking, we estimate the sequencing depths
of the experiments using a new method based on Poisson
goodness-of-fit statistic, calculate a score statistic on the
basis of a Poisson log-linear model, and then estimate the
false discovery rate using a modified version of permutation
plug-in method.

This package implements a method for normalization,
testing, and false discovery rate estimation for RNA-sequencing
data. The description of the method is in Li J, Witten DM,
Johnstone I, Tibshirani R (2012). Normalization, testing, and
false discovery rate estimation for RNA-sequencing data.
Biostatistics 13(3): 523-38. We estimate the sequencing depths
of experiments using a new method based on Poisson
goodness-of-fit statistic, calculate a score statistic on the
basis of a Poisson log-linear model, and then estimate the
false discovery rate using a modified version of permutation
plug-in method. A more detailed instruction as well as sample
data is available at
http://www.stanford.edu/~junli07/research.html.  In Version
1.1.1, we changed the way of calculating log foldchange for
two-class data. The FDR estimation part remains unchanged.

This package implements a method for normalization,
testing, and false discovery rate estimation for RNA-sequencing
data. The description of the method is in Li J, Witten DM,
Johnstone I, Tibshirani R (2012). Normalization, testing, and
false discovery rate estimation for RNA-sequencing data.
Biostatistics 13(3): 523-38. We estimate the sequencing depths
of experiments using a new method based on Poisson
goodness-of-fit statistic, calculate a score statistic on the
basis of a Poisson log-linear model, and then estimate the
false discovery rate using a modified version of permutation
plug-in method. A more detailed instruction as well as sample
data is available at
http://www.stanford.edu/~junli07/research.html.  In this
version, we changed the way of calculating log foldchange for
two-class data. The FDR estimation part remains unchanged.