c(
person("Pete", "Philipson", email = "peter.philipson1@newcastle.ac.uk",
role = "aut",
comment = c(ORCID = "0000-0001-7846-0208")),
person("Ines", "Sousa", email = "isousa@mct.uminho.pt",
role = "aut",
comment = c(ORCID = "0000-0002-2712-1713")),
person("Peter J.", "Diggle", email = "p.diggle@lancaster.ac.uk",
role = "aut",
comment = c(ORCID = "0000-0003-3521-5020")),
person("Paula", "Williamson", email = "p.r.williamson@liverpool.ac.uk",
role = "aut",
comment = c(ORCID = "0000-0001-9802-6636")),
person("Ruwanthi", "Kolamunnage-Dona", email = "kdrr@liverpool.ac.uk",
role = "aut",
comment = c(ORCID = "0000-0003-3886-6208")),
person("Robin", "Henderson", email = "robin.henderson@ncl.ac.uk",
role = "aut"),
person("Graeme L.", "Hickey", email = "graemeleehickey@gmail.com",
role = c("aut", "cre"),
comment = c(ORCID = "0000-0002-4989-0054")),
person("Maria", "Sudell", email = "m.e.sudell@liverpool.ac.uk",
role = "ctb"),
person("Medical Research Council", role = "fnd",
comment = "Grant numbers: G0400615 and MR/M013227/1")
)
Pete Philipson [aut] (<https://orcid.org/0000-0001-7846-0208>),
Ines Sousa [aut] (<https://orcid.org/0000-0002-2712-1713>),
Peter J. Diggle [aut] (<https://orcid.org/0000-0003-3521-5020>),
Paula Williamson [aut] (<https://orcid.org/0000-0001-9802-6636>),
Ruwanthi Kolamunnage-Dona [aut]
(<https://orcid.org/0000-0003-3886-6208>),
Robin Henderson [aut],
Graeme L. Hickey [aut, cre] (<https://orcid.org/0000-0002-4989-0054>),
Maria Sudell [ctb],
Medical Research Council [fnd] (Grant numbers: G0400615 and
MR/M013227/1)

Joint Modelling of Multivariate Longitudinal Data and
Time-to-Event Outcomes
c(
person("Graeme L.", "Hickey", email = "graeme.hickey@liverpool.ac.uk",
role = c("cre", "aut")),
person("Pete", "Philipson", email = "pete.philipson@northumbria.ac.uk",
role = "aut"),
person("Andrea", "Jorgensen", email = "aljorgen@liverpool.ac.uk",
role = "aut"),
person("Ruwanthi", "Kolamunnage-Dona", email = "kdrr@liverpool.ac.uk",
role = "aut"),
person("Paula", "Williamson", email = "p.r.williamson@liverpool.ac.uk",
role = "ctb")
)
Fits the joint model proposed by Henderson and colleagues (2000)
<doi:10.1093/biostatistics/1.4.465>, but extended to the case of multiple
continuous longitudinal measures. The time-to-event data is modelled using a
Cox proportional hazards regression model with time-varying covariates. The
multiple longitudinal outcomes are modelled using a multivariate version of the
Laird and Ware linear mixed model. The association is captured by a multivariate
latent Gaussian process. The model is estimated using a Monte Carlo Expectation
Maximization algorithm. This project is funded by the Medical Research Council
(Grant number MR/M013227/1).
graphics, MASS, Matrix, nlme, Rcpp (>= 0.12.7), stats,
survival, utils
Graeme L. Hickey [cre, aut],
Pete Philipson [aut],
Andrea Jorgensen [aut],
Ruwanthi Kolamunnage-Dona [aut],
Paula Williamson [ctb]