Dose Finding in Drug Combination Phase I Trials Using PO-CRM
"Varhegyi, Nikole E. (nev4g)" <nev4g@virginia.edu>
Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Dose-finding in drug combination Phase I trials using the
partial order continual reassessment method (PO-CRM).
This package provides functions to implement and simulate
the partial order continual reassessment method (PO-CRM) for
use in Phase I trials of combinations of agents. It also
provides a function for generating a set of initial guesses
(skeleton) for the toxicity probabilities at each combination
that correspond to the set of possible orderings of the
toxicity probabilities specified by the user.

This package provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) for use in Phase I trials of combinations of agents. It also provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Legacy Scottish Post Office Directories Cleaner
c(
person(
"Olivier", "Bautheac", , "olivier.bautheac@strath.ac.uk",
role = c("aut", "cre")
),
person(given = "University of Strathclyde", role = c("cph", "fnd"))
)
Attempts to clean optical character recognition (OCR) errors in
legacy Scottish Post Office Directories. Further attempts to match records from
trades and general directories.
Olivier Bautheac [aut, cre],
University of Strathclyde [cph, fnd]