An R Package for Calculating Linkage Disequilibrium
c(person(given = "Timothy A.",
family = "Myers",
role = c("aut", "cre"),
email = "myersta@mail.nih.gov"),
person(given = "Stephen J.",
family = "Chanock",
role = "aut",
email = "chanocks@mail.nih.gov"),
person(given = "Mitchell J.",
family = "Machiela",
role = "aut",
email = "mitchell.machiela@nih.gov")
)
Timothy A. Myers [aut, cre],
Stephen J. Chanock [aut],
Mitchell J. Machiela [aut]

Calculating Linkage Disequilibrium (LD) in Human Population
Groups of Interest
c(person(given = "Timothy A.",
family = "Myers",
role = c("aut", "cre"),
email = "myersta@mail.nih.gov"),
person(given = "Stephen J.",
family = "Chanock",
role = "aut",
email = "chanocks@mail.nih.gov"),
person(given = "Mitchell J.",
family = "Machiela",
role = "aut",
email = "mitchell.machiela@nih.gov"))
Provides access to the 'LDlink' API (<https://ldlink.nci.nih.gov/?tab=apiaccess>)
using the R console.  This programmatic access facilitates researchers who are
interested in performing batch queries in 1000 Genomes Project (2015) <doi:10.1038/nature15393>
data using 'LDlink'. 'LDlink' is an interactive and powerful suite of web-based tools for querying
germline variants in human population groups of interest. For more details, please see
Machiela et al. (2015) <doi:10.1093/bioinformatics/btv402>.

c(person(given = "Timothy A.",
family = "Myers",
role = c("aut", "cre"),
email = "myersta@mail.nih.gov",
comment = c(ORCID = "0000-0001-8127-3446")),
person(given = "Stephen J.",
family = "Chanock",
role = "aut",
email = "chanocks@mail.nih.gov"),
person(given = "Mitchell J.",
family = "Machiela",
role = "aut",
email = "mitchell.machiela@nih.gov",
comment = c(ORCID = "0000-0001-6538-9705")))
Timothy A. Myers [aut, cre] (<https://orcid.org/0000-0001-8127-3446>),
Stephen J. Chanock [aut],
Mitchell J. Machiela [aut] (<https://orcid.org/0000-0001-6538-9705>)

Exact tests for Linkage Disequilibrium and Hardy-Weinberg Equilibrium
Exact tests for Linkage Disequilibrium (LD) and Hardy-Weinberg Equilibrium (HWE). - 2-sided LD tests based on different measures of LD (Kulinskaya and Lewin 2008) - 1-sided Fisher's exact test for LD - 2-sided Haldane test for HWE (Wiggington 2005) - 1-sided test for inbreeding - conditional p-values proposed in Kulinskaya (2008) to overcome the problems of asymetric distributions (for both LD and HWE)