We extend existing gene enrichment tests to perform adverse
event enrichment analysis. Unlike the continuous gene expression data,
adverse event data are counts. Therefore, adverse event data has many zeros
and ties. We propose two enrichment tests. One is a modified Fisher's exact
test based on pre-selected significant adverse events, while the other is
based on a modified Kolmogorov-Smirnov statistic. We add Covariate
adjustment to improve the analysis."Adverse event enrichment tests using
VAERS" Shuoran Li, Lili Zhao (2020) <arXiv:2007.02266>.
c(
person(given = "Shuoran", family = "Li", role = c("aut"), email = "shuoranl@umich.edu"),
person(given = "Hongfan", family = "Chen", role = c("aut"), email = "chenhf@umich.edu"),
person(given = "Lili", family = "Zhao", role = c("aut"), email = "zhaolili@med.umich.edu"),
person(given = "Michael", family = "Kleinsasser", role = c("aut", "cre"), email = "mkleinsa@umich.edu"))
dplyr, magrittr, qvalue, doParallel, tidyr, modelr, foreach,
rlang, utils
Shuoran Li [aut],
Hongfan Chen [aut],
Lili Zhao [aut],
Michael Kleinsasser [aut, cre]

Model-Based Estimation of Confounder-Adjusted Attributable
Fractions
Estimates the attributable fraction in different sampling designs adjusted for measured confounders using logistic regression (cross-sectional and case-control designs), conditional logistic regression (matched case-control design) and Cox proportional hazard regression (cohort design with time-to-event outcome). The variance of the estimator is obtained by combining the delta method with the the sandwich formula.
stats, base, graphics, survival, drgee, R (>= 3.0.0)

stats, base, graphics, survival, drgee, R (>= 3.0.0),
data.table

Estimates the attributable fraction in different sampling designs
adjusted for measured confounders using logistic regression (cross-sectional
and case-control designs), conditional logistic regression (matched case-control
design), Cox proportional hazard regression (cohort design with time-to-
event outcome) and gamma-frailty model with a Weibull baseline hazard. The variance of the estimator is obtained by combining the delta
method with the the sandwich formula. Dahlqwist et al.(2016) <doi:10.1007/s10654-016-0137-7>.
stats, base, graphics, survival, drgee, stdReg, R (>= 3.3.1),
data.table