Simulate from ODE-Based Population PK/PD and Systems
Pharmacology Models
c(
person("Kyle T", "Baron", "", "kyleb@metrumrg.com", c("aut", "cre")),
person("Alan C", "Hindmarsh", "", "", c("ctb")),
person("Linda R", "Petzold", "", "", c("ctb")),
person("Bill", "Gillespie", "", "", c("ctb")),
person("Charles", "Margossian", "", "", c("ctb")),
person("Devin", "Pastoor", "", "", c("ctb")),
person("Metrum Research Group LLC", role =  c("cph"))
)
Facilitates simulation from hierarchical, ordinary
differential equation (ODE) based models typically employed in drug development.
A model specification file is created consisting of R and C++ code that
is parsed, compiled, and dynamically loaded into the R session. Input data are
passed in and simulated data are returned as R objects.  A dosing event engine
allows interventions (bolus and infusion) to be managed separately from the
model code. Differential equations are solved with the 'DLSODA' routine
in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).
'RcppExports.R' 'utils.R' 'package.R' 'generics.R'
'class_modlist.R' 'class_tgrid.R' 'class_numericlist.R'
'class_matlist.R' 'class_ev.R' 'class_derived.R'
'class_mrgmod.R' 'class_mrgsims.R' 'Aaaa.R' 'altname.R'
'annot.R' 'chain.R' 'class_build.R' 'compile.R' 'complog.R'
'covset.R' 'data_set.R' 'datasets.R' 'env.R' 'events.R'
'example.R' 'funset.R' 'idata_set.R' 'init.R' 'inven.R'
'knobs.R' 'library.R' 'matlist.R' 'matrix.R' 'mcache.R'
'model_include.R' 'modlib.R' 'modspec.R' 'mread.R'
'mrgindata.R' 'mrgsims.R' 'mrgsolve.R' 'nmxml.R' 'param.R'
'print.R' 'qsim.R' 'render.R' 'simtime.R' 'update.R'
Kyle T Baron [aut, cre],
Alan C Hindmarsh [ctb],
Linda R Petzold [ctb],
Bill Gillespie [ctb],
Charles Margossian [ctb],
Devin Pastoor [ctb],
Metrum Research Group LLC [cph]

lattice, testthat, xml2 (>= 1.2.0), rmarkdown
'RcppExports.R' 'utils.R' 'package.R' 'generics.R'
'class_modlist.R' 'class_tgrid.R' 'class_numericlist.R'
'class_matlist.R' 'class_ev.R' 'class_derived.R'
'class_mrgmod.R' 'class_mrgsims.R' 'Aaaa.R' 'annot.R' 'chain.R'
'class_build.R' 'compile.R' 'data_set.R' 'datasets.R' 'env.R'
'events.R' 'funset.R' 'idata_set.R' 'init.R' 'inven.R'
'knobs.R' 'matlist.R' 'matrix.R' 'mcache.R' 'mcode.R'
'model_include.R' 'modlib.R' 'modspec.R' 'mread.R'
'mrgindata.R' 'mrgsims.R' 'mrgsolve.R' 'nmxml.R' 'param.R'
'print.R' 'qsim.R' 'realize_addl.R' 'relabel.R' 'render.R'
'update.R'