Improved Laplace approximation for integrals of unimodal functions.
The method requires user-supplied R functions for: the integrand, its gradient
and its Hessian matrix. The computations are run in parallel.

Multi-Reader, Multi-Case Analysis Methods (ROC, Agreement, and
Other Metrics)
Do Multi-Reader, Multi-Case (MRMC) analyses of data from imaging studies where clinicians (readers)
evaluate patient images (cases). What does this mean? ... Many imaging studies are designed
so that every reader reads every case in all modalities, a fully-crossed study. In this case, the
data is cross-correlated, and we consider the readers and cases to be cross-correlated random effects.
An MRMC analysis accounts for the variability and correlations from the readers and cases when
estimating variances, confidence intervals, and p-values. The functions in this package can treat
arbitrary study designs and studies with missing data, not just fully-crossed study designs.
The initial package analyzes the reader-average area under the receiver operating characteristic (ROC)
curve with U-statistics according to Gallas, Bandos, Samuelson,
and Wagner 2009 <doi:10.1080/03610920802610084>.
Additional functions analyze other endpoints with U-statistics (binary performance
and score differences) following the work by Gallas, Pennello, and Myers 2007
<doi:10.1364/JOSAA.24.000B70>.
Package development and documentation is at <https://github.com/DIDSR/iMRMC/tree/master>.

Implements likelihood based methods for mediation analysis proposed in Wang (2016) and Wang (2017).

Implements likelihood based methods for mediation analysis.

Likelihood Methods for Mediation Analysis

person("Scott", "Lougheed", email = "info@scottlougheed.com", role = c("aut", "cre"))
Send 'iMessages' from R running 'macOS' 10.8.x or later. You must have 'Messages.app' configured for the user account you are running R on.

Interpolation and Extrapolation for Species Diversity
Provides simple functions to compute and plot two
types (sample-size- and coverage-based) rarefaction and extrapolation of species
diversity (Hill numbers) for individual-based (abundance) data or sampling-unit-
based (incidence) data.
testthat, knitr, rmarkdown, gridExtra, ggthemes