Performs comparative bioavailability calculations for Average Bioequivalence with
Expanding Limits (ABEL). Implemented are 'Method A' and 'Method B' and the detection of outliers.
If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to
control the consumer risk.
Average Bioequivalence - optionally with a tighter (narrow therapeutic index drugs) or wider
acceptance range (Gulf Cooperation Council, South Africa: Cmax) - is implemented as well.

c(person("Helmut", "Schütz",
email = "helmut.schuetz@bebac.at",
role = c("aut", "cre"),
comment = c(ORCID = "0000-0002-1167-7880")),
person("Michael", "Tomashevskiy",
email = "mittyright@yandex.ru",
role = "ctb"),
person("Detlew", "Labes",
email = "DetlewLabes@gmx.de",
role = "ctb"))
readxl (>= 1.0.0), PowerTOST (>= 1.3.3), lmerTest, nlme,
graphics, grDevices
Performs comparative bioavailability-calculations for the
EMA's Average Bioequivalence with Expanding Limits (ABEL).
Implemented are 'Method A' and 'Method B', detection of
outliers. If the design allows, assessment of the empiric
Type I Error and iteratively adjusting alpha to preserve the
consumer risk.
Average Bioequivalence (ABE) - optionally with tighter
(EMA: NTIDs) or wider limits (GCC: Cmax) - is implemented
as well.
Helmut Schütz [aut, cre] (<https://orcid.org/0000-0002-1167-7880>),
Michael Tomashevskiy [ctb],
Detlew Labes [ctb]

c(person(given = "Helmut",
family = "Schütz",
role = c("aut", "cre"),
email = "helmut.schuetz@bebac.at",
comment = c(ORCID = "0000-0002-1167-7880")),
person(given = "Michael",
family = "Tomashevskiy",
role = "ctb",
email = "mittyright@yandex.ru"),
person(given = "Detlew",
family = "Labes",
role = "ctb",
email = "DetlewLabes@gmx.de",
comment = c(ORCID = "0000-0003-2169-426X")))
readxl (>= 1.0.0), PowerTOST (>= 1.5.3), lmerTest, nlme,
pbkrtest, graphics, grDevices

c(person(given = "Helmut", family = "Schütz",
role = c("aut", "cre"),
email = "helmut.schuetz@bebac.at",
comment = c(ORCID = "0000-0002-1167-7880")),
person(given = "Michael", family = "Tomashevskiy",
role = "ctb",
email = "mittyright@yandex.ru"),
person(given = "Detlew", family = "Labes",
role = "ctb",
email = "DetlewLabes@gmx.de",
comment = c(ORCID = "0000-0003-2169-426X")))