person("Sarah", "Davidson", email = "davidson.sarah.e@epa.gov",
person("Miyuki", "Breen", email = "breen.miyuki@epa.gov",
person("Nisha", "Sipes", email = "sipes.nisha@epa.gov",
person("Woodrow", "Setzer", email = "setzer.woodrow@epa.gov",
Copyright: This package is primarily developed by employees of the U.S.
Federal government as part of their official duties and is

high-throughput experiments. Both physiologically-based ("PBTK")
in vitro-in vivo extrapolation ("IVIVE") of high-throughput
person("Caroline", "Ring", email = "Ring.Caroline@epa.gov",
person("Matt", "Linakis", email = "MLINAKIS@ramboll.com",
person("Dustin", "Kapraun", email = "kapraun.dustin@epa.gov",
graphics, utils, magrittr, purrr, methods, Rdpack
stringr, reshape, reshape2, viridis, CensRegMod, gmodels,
colorspace, cowplot, ggrepel, dplyr, forcats, smatr, gridExtra,

Description: Pre-made models that can be rapidly tailored to various chemicals
and species using chemical-specific in vitro data and physiological
information. These tools allow incorporation of chemical
toxicokinetics ("TK") and in vitro-in vivo extrapolation ("IVIVE")
into bioinformatics, as described by Pearce et al. (2017)
in vitro data characterizing toxicokinetics can be been obtained
from relatively high-throughput experiments. The
("generic") physiologically-based ("PBTK") and empirical
(for example, one compartment) "TK" models included here can be
parameterized with in vitro data or in silico predictions which are
provided for thousands of chemicals, multiple exposure routes,
and various species. The models are systems of ordinary
included for simulating human biological variability
(Wambaugh et al., 2019 <doi:10.1093/toxsci/kfz205>).
Empirically calibrated methods are included for predicting
tissue:plasma partition coefficients and volume of distribution
These functions and data provide a set of tools for using IVIVE to
convert concentrations from high-throughput screening experiments
(for example, Tox21, ToxCast) to real-world exposures via reverse
stringr, reshape, reshape2, viridis, gmodels, colorspace,
cowplot, ggrepel, dplyr, forcats, smatr, gridExtra, testthat