Description: The core of this 'Rcpp' based package is several functions to estimate the baseline hazard, frailty variance, and fixed effect parameter for a discrete-time shared frailty model with random effects. The functions are designed to analyze grouped time-to-event data accounting for family structure of related individuals (i.e., trios). The core functions include two processes: (1) evaluate the multivariable integration to compute the exact proportional hazards model based likelihood and (2) estimate the desired parameters using maximum likelihood estimation. The integration is evaluated by the 'Cuhre' algorithm from the 'Cuba' library (Hahn, T., Cuba-a library for multidimensional numerical integration, Comput. Phys. Commun. 168, 2005, 78-95 <doi:10.1016/j.cpc.2005.01.010>), and the source files of the 'Cuhre' function are included in this package. The maximization process is carried out using Brent's algorithm, with the 'C++' code file from John Burkardt and John Denker (Brent, R.,Algorithms for Minimization without Derivatives, Dover, 2002, ISBN 0-486-41998-3).

Package: lclGWAS
Type: Package
Title: Efficient Estimation of Discrete-Time Multivariate Frailty Model
Using Exact Likelihood Function for Grouped Survival Data
Version: 1.0
Date: 2016-11-10
Author: Jiaxing Lin, Alexander Sibley, Tracy Truong, Nancy Cox, Eileen Dolan, Yu
Jiang, Janice McCarthy, Andrew Allen, Kouros Owzar, Zhiguo Li
Maintainer: Jiaxing Lin <jiaxing.lin@duke.edu>
Description: The core of this 'Rcpp' based package is several functions to
compute the baseline hazard, effect parameter, and frailty variance for the
discrete-time shared frailty model with random effects. The core functions
include two processes: (1) evaluate the multiple variable integration to
compute the exact proportional hazards model based likelihood and (2) estimate
desired parameters using maximum likelihood estimation. The integration is
evaluated by 'Cuhre' function from 'Cuba' library (Hahn, T., Cuba-a library
for multidimensional numerical integration, Comput. Phys. Commun. 168, 2005,
78-95 <doi: 10.1016/j.cpc.2005.01.010>), and the source files of 'Cuhre' function are included in this package.
Maximization process is carried out using the Brent's algorithm, and the 'C+
+' code file is from John Burkardt and John Denker (Brent, R.,Algorithms for
Minimization without Derivatives, Dover, 2002, ISBN 0-486-41998-3).
License: GPL (>= 2)
Imports: Rcpp (>= 0.12.4),
LinkingTo: Rcpp, BH
Suggests: knitr
VignetteBuilder: knitr
BuildVignettes: yes
NeedsCompilation: yes
Packaged: 2016-11-14 20:52:39 UTC; jl354
Repository: CRAN
Date/Publication: 2016-11-15 00:18:41