Description: Loading NONMEM (NONlinear Mixed-Effect Modeling, <https://www.iconplc.com/innovation/nonmem/>) and PSN (Perl-speaks-NONMEM, <https://uupharmacometrics.github.io/PsN/>) output files to extract parameter estimates, provide visual predictive check (VPC) and goodness of fit (GOF) plots, and simulate with parameter uncertainty.

Title: Create and Evaluate NONMEM Models in a Project Context
Description: Systematically creates and modifies NONMEM(R) control streams. Harvests
NONMEM output, builds run logs, creates derivative data, generates diagnostics.
NONMEM (ICON Development Solutions <http://www.iconplc.com/>) is software for
nonlinear mixed effects modeling. See 'package?nonmemica'.
Imports: dplyr, tidyr, xml2, encode, csv, fold, spec, lazyeval,
Suggests: ReporteRs, pander, knitr, wrangle

Imports: dplyr (>= 0.7.1), tidyr, xml2, encode, csv, fold (>= 0.2.1),
spec, lazyeval, metaplot (>= 0.1.4), magrittr, rlang

Imports: dplyr (>= 0.7.1), tidyr, xml2, encode, csv, spec, lazyeval,

Suggests: ReporteRs, pander, knitr, wrangle, rmarkdown

Suggests: pander, knitr, wrangle, rmarkdown

Packaged: 2020-03-25 16:36:03 UTC; tim.bergsma

Packaged: 2020-10-02 18:07:28 UTC; tim.bergsma

Packaged: 2020-10-21 14:30:14 UTC; tim.bergsma

Packaged: 2020-11-23 23:03:21 UTC; tim.bergsma

NONMEM (ICON Development Solutions <https://www.iconplc.com/>) is software for
Packaged: 2022-10-01 00:16:38 UTC; tim.bergsma

Description: Minimize a differentiable function subject to all the variables being non-negative (i.e. >= 0),
using a Conjugate-Gradient algorithm based on a modified Polak-Ribiere-Polyak formula as described in

using a Conjugate-Gradient algorithm based on a modified Polak-Rubiere-Polyak formula as described in

Description: Testing non-nested models via theory supplied by Vuong (1989).
Includes tests of model distinguishability and of model fit that
can be applied to both nested and non-nested models.  Also includes
functionality to obtain confidence intervals associated with AIC and BIC.

Description: Object-oriented testing and comparison of pairs of models,
using theory supplied by Vuong (1989).  vuongtest includes
tests of model equivalence, likelihood ratio-like
tests of non-nested models, and confidence intervals associated with