Description: 'ACE' (Advanced Cohort Engine) is a powerful tool that allows constructing cohorts of patients
extremely quickly and efficiently. This package is designed to interface directly with an
instance of 'ACE' search engine and facilitates API queries and data dumps. Prerequisite
is a good knowledge of the temporal language to be able to efficiently construct a query.
More information available at <https://shahlab.stanford.edu/start>.

Title: ACE Kin Pair Data Simulations and Model Fitting
c(person("Xuanyu", "Lyu", email = "lyux20@wfu.edu", role = c("aut", "cre")),
person("S.Mason", "Garrison",email = "garrissm@wfu.edu", role = "aut"))
Description: A few functions aim to provide a statistic tool for three purposes. First, simulate kin pairs data based on the assumption that every trait is affected by genetic effects (A), common environmental effects (C) and unique environmental effects (E).Second, use kin pairs data to fit an ACE model and get model fit output.Third, calculate power of A estimate given a specific condition. For the mechanisms of power calculation, we suggest to check Visscher(2004)<doi:10.1375/twin.7.5.505>.
Suggests: knitr, testthat (>= 3.0.0), rmarkdown

Title: Estimating Age Modification Effect on Genetic and Environmental
Description: Two novel twin models that are able to estimate the dynamic behaviour of the variance components in the classical twin models with respect to age.

Imports: Rcpp (>= 0.11.1), splines, MASS

Description: Twin models that are able to estimate the dynamic behaviour of the variance components in the classical twin models with respect to age using B-splines and P-splines.

Suggests: knitr (>= 1.12.1), rmarkdown (>= 0.9.5)

Title: Estimating Dynamic Heritability and Twin Model Comparison

Title: Estimation of Dynamic Heritability and Comparison of Twin Models
Authors@R: person("Liang", "He", email = "liang.he@duke.edu",role = c("aut", "cre"))
Description: Estimate the dynamic behaviour of the variance components in the classical twin models with respect to age using B-splines and P-splines.