Description: Provides a general framework for clinical trial simulations based
on the Clinical Scenario Evaluation (CSE) approach. The package supports a
broad class of data models (including clinical trials with continuous, binary,
survival-type and count-type endpoints as well as multivariate outcomes that are
based on combinations of different endpoints), analysis strategies and commonly

Imports: doParallel, doRNG, foreach, MASS, mvtnorm, stats, survival,
Suggests: knitr, ReporteRs, rmarkdown, pander

Suggests: flextable, knitr, officer, rmarkdown, pander

Title: Power and Sample Size Calculations for Clinical Trials
person("Alex", "Dmitrienko", email = "admitrienko@mediana.us", role = c("aut", "cre")))
Imports: Rcpp (>= 0.12.10), RcppNumerical, methods, officer, flextable,
devEMF, mvtnorm, shiny, shinydashboard, shinyMatrix, foreach,
parallel, doParallel, doRNG, MASS, rootSolve, lme4, lmerTest,
Efficient simulation-based power and sample size calculations are supported for a
broad class of late-stage clinical trials. The following modules are included in
Adaptive designs with data-driven sample size or event count re-estimation,
Adaptive designs with data-driven treatment selection,
Adaptive designs with data-driven population selection,
Optimal selection of a futility stopping rule,
Event prediction in event-driven trials,
Adaptive trials with response-adaptive randomization (experimental module),
Traditional trials with multiple objectives (experimental module).
Traditional trials with cluster-randomized designs (experimental module).
Packaged: 2022-10-29 08:04:21 UTC; victordmitrienko

Title: Efficient Simulation-Based Power and Sample Size Calculations
for a Broad Class of Late-Stage Clinical Trials
Imports: Rcpp (>= 0.12.10), officer, flextable, devEMF, shiny,
The following modules are included in the package:
Event prediction in event-driven trials.
Packaged: 2021-07-25 12:26:50 UTC; victordmitrienko

Imports: Rcpp (>= 0.12.10), RcppEigen, RcppNumerical, officer,
flextable, devEMF, mvtnorm, shiny, shinydashboard, shinyMatrix
Packaged: 2021-08-14 23:00:40 UTC; victordmitrienko