SystemRequirements: gsl (with development libraries)
Packaged: 2011-12-09 19:57:36 UTC; joshuamillstein

Description: This package implements a formal statistical hypothesis test, resulting in a p-value, to quantify uncertainty in a causal inference pertaining to a measured factor, e.g. a molecular species, which potentially mediates a known causal association between a locus and a quantitative trait. The test is applicable to data that includes genotype (discrete), possible causal mediator such as gene expression (continuous) and an outcome of interest (continuous).
Packaged: 2013-12-19 23:10:57 UTC; joshuamillstein

Packaged: 2014-12-09 22:43:14 UTC; joshuamillstein

Description: A formal statistical hypothesis test, resulting in a p-value, is provided to quantify uncertainty in a causal inference pertaining to a measured factor, e.g. a molecular species, which potentially mediates a known causal association between a locus and a quantitative trait. The test is applicable to data that includes genotype (discrete), possible causal mediator such as gene expression (continuous) and an outcome of interest (continuous).
Packaged: 2015-03-10 17:28:01 UTC; joshuamillstein

Description: A likelihood-based hypothesis testing approach is implemented for assessing causal mediation. For example, it could be used to test for mediation of a known causal association between a DNA variant, the 'instrumental variable', and a clinical outcome or phenotype by gene expression or DNA methylation, the potential mediator. Another example would be testing mediation of the effect of a drug on a clinical outcome by the molecular target. The hypothesis test generates a p-value or permutation-based FDR value with confidence intervals to quantify uncertainty in the causal inference. The outcome can be represented by either a continuous or binary variable, the potential mediator is continuous, and the instrumental variable can be continuous or binary and is not limited to a single variable but may be a design matrix representing multiple variables.
Packaged: 2015-10-24 19:16:53 UTC; joshuamillstein