Title: Estimation of Recombination Rate and Maternal LD in Half-Sibs
Description: Paternal recombination rate and maternal linkage disequilibrium
(LD) are estimated for pairs of biallelic markers such as single nucleotide
polymorphisms (SNPs) from progeny genotypes and sire haplotypes. At least
one sire has to be double heterozygous at the investigated pairs of SNPs.
The implementation relies on paternal half-sib families. If maternal half-
sib families are used, the roles of sire/dam are swapped. Multiple families
Hampel, Teuscher, Gomez-Raya, Doschoris, Wittenburg (2018) "Estimation of
recombination rate and maternal linkage disequilibrium in half-sibs"
Gomez-Raya (2012) "Maximum likelihood estimation of linkage disequilibrium
Imports: Rcpp (>= 1.0.3), hsphase, dplyr, data.table, rlist
Packaged: 2020-02-25 13:16:25 UTC; wittenburg

Imports: Rcpp (>= 1.0.3), hsphase, dplyr, data.table, rlist, quadprog
Packaged: 2020-05-28 07:51:25 UTC; wittenburg

Suggests: knitr, rmarkdown, AlphaSimR, doParallel, ggplot2
Packaged: 2020-08-17 09:07:33 UTC; wittenburg

Suggests: knitr, rmarkdown, formatR, AlphaSimR (>= 0.13.0), doParallel,
Packaged: 2020-10-13 13:06:21 UTC; wittenburg

polymorphisms (SNPs) from progeny genotypes and sire haplotypes. The
implementation relies on paternal half-sib families. If maternal half-sib
families are used, the roles of sire/dam are swapped. Multiple families can
be considered. For parameter estimation, at least one sire has to be double
heterozygous at the investigated pairs of SNPs.
Based on recombination rates, genetic distances between markers can be
estimated. Markers with unusually large recombination rate to markers in
close proximity can be discarded in this derivation.
Imports: Rcpp (>= 1.0.3), hsphase, dplyr, data.table, rlist, quadprog,
Packaged: 2021-03-23 07:57:43 UTC; wittenburg

close proximity (i.e. putatively misplaced markers) shall be discarded in
A workflow description is attached as vignette.
Packaged: 2022-03-24 07:35:05 UTC; wittenburg

Packaged: 2022-03-25 06:46:43 UTC; wittenburg