Title: Generating Various Molecular Representations for Chemicals,
Proteins, DNAs, RNAs and Their Interactions
Description: Calculating 293 chemical descriptors and 14 kinds of chemical fingerprints, 9920 protein descriptors based on protein sequences, more than 6000 DNA/RNA descriptors from nucleotide sequences, and six types of interaction descriptors using three different combining strategies.
Author: Min-feng Zhu <wind2zhu@163.com>, Jie Dong <biomed@csu.edu.cn>,
SystemRequirements: Java JDK 1.8 or higher
Imports: RCurl, rjson, rcdk (>= 3.3.2), Biostrings, GOSemSim,
ChemmineR, fmcsR, pls, randomForest, utils, stats, graphics,
biocViews: Software, DataImport, DataRepresentation, FeatureExtraction,

Imports: RCurl, rjson, rcdk (>= 3.3.2), Biostrings, GOSemSim, MASS,

Title: Biomarker Prognostic Enrichment Tool
Authors@R: c(person("Jeremy", "Roth", email = "jhroth@uw.edu", role = c("aut", "cre")),
person("Kathleen", "F. Kerr", email = "katiek@uw.edu", role = c("aut")),
person("Kathlee", "Zhu", email = "zhukehao@uw.edu", role = c("aut")))
Description: Prognostic Enrichment is a clinical trial strategy of evaluating an intervention in a patient population with a higher rate of the unwanted event than the broader patient population (R. Temple (2010) <DOI:10.1038/clpt.2010.233>). This higher event rate translates to a lower sample size for the clinical trial, which can have both practical and ethical advantages. This package is a tool to help evaluate biomarkers for prognostic enrichment of clinical trials.

Authors@R: c(person("Jeremy", "Roth", email = "jhroth@uw.edu", role=c("cre", "aut")),
person("Kathleen", "F. Kerr", email = "katiek@uw.edu", role="aut"),
person("Kehao", "Zhu", email = "zhukehao@uw.edu", role="aut"))
Description: Prognostic Enrichment is a clinical trial strategy of evaluating an intervention in a patient population with a higher rate of the unwanted event than the broader patient population (R. Temple (2010) <DOI:10.1038/clpt.2010.233>). A higher event rate translates to a lower sample size for the clinical trial, which can have both practical and ethical advantages. This package is a tool to help evaluate biomarkers for prognostic enrichment of clinical trials.