Packaged: 2021-07-07 15:21:41 UTC; victordmitrienko

Imports: Rcpp (>= 0.12.10), RcppNumerical, officer, flextable, devEMF,
Adaptive trials with response-adaptive randomization (experimental module).
Packaged: 2021-09-17 02:18:48 UTC; victordmitrienko

Packaged: 2021-10-05 02:28:21 UTC; victordmitrienko

Packaged: 2021-10-10 13:15:32 UTC; victordmitrienko

mvtnorm, shiny, shinydashboard, shinyMatrix, foreach, parallel,
Packaged: 2021-12-19 03:20:43 UTC; victordmitrienko

Packaged: 2022-06-24 14:39:44 UTC; victordmitrienko

The package supports efficient simulation-based power and sample size
calculations for a broad class of late-stage clinical trials. The following modules are included in the package:
Packaged: 2022-10-20 13:01:51 UTC; victordmitrienko

Title: Accessing and Processing a 'Mega2' Genetic Database
Description: Uses as input genetic data that have been reformatted
and stored in a 'SQLite' database; this database is initially
created by the standalone 'mega2' C++ program (available freely
manipulates data frames containing genotype, phenotype, and family
information from the input 'SQLite' database, and decompresses
needed subsets of the genotype data, on the fly, in a memory
efficient manner.  We have also created several more functions that
illustrate how to use the data frames as well as perform useful
tasks: these permit one to run the 'pedgene' package to carry out
gene-based association tests on family data using selected marker
subsets, to run the 'SKAT' package to carry out gene-based
association tests using selected marker subsets, to output the
'Mega2R' data as a VCF file and related files (for phenotype and
family data), and to convert the data frames into 'GenABEL'
Authors@R: c(person(c("Robert","V."), "Baron", email = "rvb5@pitt.edu",  role = c("aut")),
person(c("Daniel","E."), "Weeks",    email = "weeks@pitt.edu", role = c("aut","cre")),
Depends: R (>= 3.3.3), GenABEL, SKAT, pedgene,
Imports: AnnotationDbi, DBI, GenomeInfoDb, RSQLite, methods
Suggests: knitr, rmarkdown, formatR, TxDb.Hsapiens.UCSC.hg19.knownGene,
Maintainer: Daniel E. Weeks <weeks@pitt.edu>