Title: Guide Sequence Design for CRISPR/Cas9
person("Dylan", "Beeber", email = "dylan.beeber@gmail.com", role = c("aut", "cre")),
person("Frederic", "Chain", role = "aut"))
Description: Designs guide sequences for CRISPR/Cas9 genome editing and
provides information on sequence features pertinent to guide
efficiency. Sequence features include annotated off-target
predictions in a user-selected genome and a predicted efficiency
score based on the model described in Doench et al. (2016)
<doi:10.1038/nbt.3437>. Users are able to import additional genomes
and genome annotation files to use when searching and annotating
off-target hits. All guide sequences and off-target data can be
generated through the 'R' console with sgRNA_Design() or through
'crispRdesignR's' user interface with crispRdesignRUI(). CRISPR
(Clustered Regularly Interspaced Short Palindromic Repeats) and the
associated protein Cas9 refer to a technique used in genome editing.
Imports: Biostrings, gbm, GenomicRanges, BiocGenerics, IRanges,
GenomeInfoDb, S4Vectors, rtracklayer, stringr, vtreat, shiny,

Title: Modeling Fissile Material Operations in Nuclear Facilities
person("Will", "Zywiec", , "willzywiec@gmail.com", role = c("aut", "cre"),
Description: A collection of functions for modeling fissile material operations in nuclear facilities,
Imports: bnlearn, caret, dplyr, evd, fitdistrplus, ggplot2, keras,
Author: Will Zywiec [aut, cre] (<https://orcid.org/0000-0002-1842-9599>)

Title: An Implementation of the Critical Path Method
person("Rubens Jose", "Rosa", role=c("aut", "cre"), email = "rubens@rubensjoserosa.com"),
person("Marcos", "dos Santos", role="aut", email="marcosdossantos@ime.eb.br"),
Maintainer: Rubens Jose Rosa <rubens@rubensjoserosa.com>
An R6 object oriented implementation of the Critical Path Method (CPM).
CPM is a method used to estimate the minimum project duration and determine
the amount of scheduling flexibility on the logical network paths within the
schedule model. The flexibility is in terms of early start, early finish,
late start, late finish, total float and free float. Beside, it permits
to quantify the complexity of network diagram through the analysis of
topological indicators. Finally, it permits to change the activities duration
to perform what-if scenario analysis. The package was built based on following
references: To make topological sorting and other graph operation, we use
For schedule concept, the reference was Project Management Institute (2017)
For standards terms, we use Project Management Institute (2017)
For algorithms on Critical Path Method development, we use
And, finally, for topological definitions, we use
Suggests: DiagrammeR, knitr, rmarkdown, testthat