Description: The target equivalence range (TEQR) design, previously named the toxicity equivalence range design is an up-down design patterned after the modified toxicity probability interval design.The TEQR design extends the well known 3+3 design to allow for: an explicit target range for the dose limiting toxicity (DLT) rate, more subjects at the maximum tolerated dose (MTD), and specification of a too-toxic rate, which closes a dose level, In addition, the TEQR design can be implemented to target a dose based either on toxicity rate or activity rate constrained for toxicity.
Packaged: 2013-07-09 16:17:21 UTC; SBlanchard

Packaged: 2014-06-14 16:21:47 UTC; SBlanchard

Packaged: 2014-07-18 18:56:55 UTC; SBlanchard

Description: The TEQR package contains software to calculate the operating characteristics for the TEQR and the ACT designs.The TEQR (toxicity equivalence range) design is a toxicity based cumulative cohort design with added safety rules. The ACT (Activity constrained for toxicity) design  is also a cumulative cohort design with additional safety rules. The unique feature of this design is that dose is escalated based on lack of activity rather than on lack of toxicity and is de-escalated only if an unacceptable level of toxicity is experienced.
Packaged: 2016-02-05 15:20:43 UTC; SBlanchard

Title: Test for A+B Traditional Escalation Rule
Description: This package is for the comparison of various types of A+B
escalation rules for dose finding trials.

Title: Fast simulation of reconstructed phylogenetic trees under
Description: TESS is a package for simulation of reconstructed
phylogenetic trees under global, time-dependent birth-death
processes. Speciation and extinction rates can be any function
of time and mass-extinction events at specific times can be
provided. Trees can be simulated either conditioned on the
number of species, the time of the process, or both.
Additionally, the likelihood equations are implemented for
convenience and can be used for Maximum Likelihood (ML)