Package: plethem
Title: Population Life Course Exposure to Health Effects Modeling
Version: 1.1.0
Authors@R: c(
person("Salil", "Pendse", email = "spendse@scitovation.com", role = c("aut")),
person("Kevin","Bronson",email = "kbronson@scitovation.com",role = c("aut")),
person("Jeremy","Fitzpatrick",email = "jfitzpatrick@scitovation.com",role = c("aut", "cre")),
person("Patrick","McMullen",email = "pmcmullen@scitovation.com",role="ctb"),
person("ScitoVation, LLC",role ="cph")
)
Description: Functions, data and user interfaces for performing physiologically
based pharmacokinetic ('PBPK') modeling, in-vitro-to-in-vivo Extrapolation
('IVIVE') and exposure estimation. Also contains user interfaces to run
models from the 'httk' package. Taken together these provide an easy to use
and powerful modeling tool that can be used for all steps along
the source-to-outcome continuum.All the analysis tools in the package are
run as interactive applications. Check package help for more
information. Refer to the manuscript 'Population Life-course exposure to
health effects model (PLETHEM): An R package for PBPK modeling'
<doi: 10.1016/j.comtox.2019.100115> for more information on the models and
algorithms used in the package. More information on PBPK modeling itself
can be found in the book 'Physiologically Based Pharmacokinetic Modeling:
Science and Applications' by Reddy et al <doi:10.1002/0471478768>.
Depends: R (>= 3.6.0)
License: MIT + file LICENSE
URL: https://github.com/ScitoVation/plethem/
BugReports: https://github.com/ScitoVation/plethem/issues/
Encoding: UTF-8
LazyData: true
Imports: shiny, ggplot2, shinyBS, shinyWidgets, miniUI, shinydashboard,
rstudioapi, shinythemes, rhandsontable, deSolve, truncdist,
reshape2, dplyr, readxl, gdata, devtools, RSQLite, formatR,
plotly, magrittr, sqldf, utils, stats, DT, shinyjs, V8, httk,
NonCompart, stringr, doParallel, foreach, pracma, shinybusy,
data.table, tidyr, shinyalert, shinyFiles, officer, DiagrammeR,
DiagrammeRsvg, rsvg, devEMF
Suggests: testthat, shinytest, rmarkdown, knitr
RoxygenNote: 7.1.1
VignetteBuilder: knitr
NeedsCompilation: yes
Packaged: 2020-10-28 13:43:37 UTC; jfitzpatrick
Author: Salil Pendse [aut],
Kevin Bronson [aut],
Jeremy Fitzpatrick [aut, cre],
Patrick McMullen [ctb],
ScitoVation, LLC [cph]
Maintainer: Jeremy Fitzpatrick <jfitzpatrick@scitovation.com>
Repository: CRAN
Date/Publication: 2020-11-04 15:50:07 UTC