Title: Summary based Conditional Association Test
Description: Conditional association test based on summary data from genome-wide association study (GWAS) adjusting for heterogeneity in SNP coverage.

Title: Summary Based Conditional Association Test
Description: Conditional association test based on summary data from genome-wide association study (GWAS). SCAT adjusts for heterogeneity in SNP coverage that exists in summary data if SNPs are not present in all of the participating studies of a GWAS meta-analysis. This commonly happens when different reference panels are used in participating studies for genotype imputation. This could happen when ones simply do not have data for some SNPs (e.g. different array, or imputated data is not available). Without properly adjusting for this kind of heterogeneity leads to inflated false positive rate. SCAT can also be used to conduct conventional conditional analysis when coverage heterogeneity is absent. For more details, refer to Zhang et al. (2018) Brief Bioinform. 19(6):1337-1343. <doi: 10.1093/bib/bbx072>.

Title: Identifies Mean, Variance, and Hierarchically Clustered
Author: Erika S. Helgeson, Qian Liu, Guanhua Chen, Michael R. Kosorok , and Eric Bair
Maintainer: Erika S. Helgeson <helge@umn.edu>
Description: Identifies a bicluster, a submatrix of the data such that the features and observations within the submatrix differ from those not contained in submatrix, using a two-step method. In the first step, observations in the bicluster are  identified to maximize the sum of weighted between cluster feature differences. The observations are identified in a similar fashion as in Witten and Tibshirani (2010) <doi:10.1198/jasa.2010.tm09415> except with a modified objective function and no feature sparsity constraint. In the second step, features in the bicluster are identified based on their contribution to the clustering of the observations. The cluster significance test of Liu, Hayes, Nobel, and Marron (2008): <doi:10.1198/016214508000000454> can then be used to test the strength of the identified bicluster. 'SCBiclust' can be used to identify biclusters which differ based on feature means, feature variances, or more general differences.