Packaged: 2015-10-27 04:14:49 UTC; joshuamillstein

Packaged: 2015-10-28 22:31:40 UTC; joshuamillstein

Packaged: 2016-01-10 16:19:12 UTC; joshuamillstein

Packaged: 2016-03-07 17:37:38 UTC; joshuamillstein

Packaged: 2017-12-15 20:30:07 UTC; joshuamillstein

Authors@R: person("Joshua", "Millstein", email = "joshua.millstein@usc.edu", role =
Description: A likelihood-based hypothesis testing approach is implemented for
assessing causal mediation. Described in Millstein, Chen, and Breton (2016),
<DOI:10.1093/bioinformatics/btw135>, it could be used to test for mediation
of a known causal association between a DNA variant, the 'instrumental variable',
and a clinical outcome or phenotype by gene expression or DNA methylation, the
potential mediator. Another example would be testing mediation of the effect
of a drug on a clinical outcome by the molecular target. The hypothesis test
generates a p-value or permutation-based FDR value with confidence intervals
to quantify uncertainty in the causal inference. The outcome can be represented
by either a continuous or binary variable, the potential mediator is continuous,
and the instrumental variable can be continuous or binary and is not limited to
a single variable but may be a design matrix representing multiple variables.
SystemRequirements: gsl (with development libraries libgsl-dev)
Author: Joshua Millstein [aut, cre] (<https://orcid.org/0000-0001-7961-8943>)

Authors@R: c(person("Jan Philipp", "Dietrich", email = "dietrich@pik-potsdam.de", role = c("aut","cre")))
Description: A collection of functions to extract citation information from 'R' packages and to deal with files in 'citation file format' (<https://citation-file-format.github.io/>), extending the functionality already provided by the citation() function in the 'utils' package.
Maintainer: Jan Philipp Dietrich <dietrich@pik-potsdam.de>

person("Jan Philipp", "Dietrich", email = "dietrich@pik-potsdam.de", role = c("aut","cre")),
person("Waldir", "Leoncio", email = "w.l.netto@medisin.uio.no", role = c("aut")))
Imports: desc, jsonlite, utils, withr, yaml
Author: Jan Philipp Dietrich [aut, cre],