Title: Compute the Personalized Activity Index via flexible Bayesian
Description: The functions in this package implement the safety monitoring procedures proposed in the paper titled "A flexible mixed effect negative binomial regression model for detecting unusual increases in MRI lesion counts in individual multiple sclerosis patients" by Kondo Y, Zhao Y and Petkau AJ. The procedure first models longitudinally collected count variables with a negative binomial mixed-effect regression model. To account for the correlation among repeated measures from the same patient, the model has subject-specific random intercept, which is modelled with infinite mixture of Beta distributions, very flexible distribution that theoretically allows any form. The package also has the option of single beta distribution for random effects. These mixed-effect models could be useful beyond the application of the safety monitoring. The inference is based on MCMC samples and this package contains a Gibbs sampler to sample from the posterior distribution of the negative binomial mixed-effect regression model. Based on the fitted model, the personalized activity index is computed for each patient. Lastly, this package is companion to R package lmeNB, which contains the functions to compute the Personalized Activity Index in frequentist framework.

Description: Add smoothing spline modelling capability to nlme. Fit smoothing
spline terms in Gaussian linear and nonlinear mixed-effects models

Description: Add smoothing spline modelling capability to nlme. Fit
smoothing spline terms in Gaussian linear and nonlinear

Title: Add smoothing spline modelling capability to nlme.

Title: Add Smoothing Spline Modelling Capability to `nlme`
Description: Adds smoothing spline modelling capability to nlme. Fits

Title: Testing for a subset of variance components in linear mixed
Description: Test zero variance components in linear mixed models and
test additivity in nonparametric regression
using the restricted likelihood ratio test and the generalized F-test.