Package: Haplin
Type: Package
Title: Analyzing case-parent triad and/or case-control data with SNP
haplotypes
Version: 5.0
Date: 2013-02-05
Author: Hakon K. Gjessing
Maintainer: Hakon K. Gjessing <hakon.gjessing@fhi.no>
Depends: MASS, mgcv, parallel, GenABEL, DatABEL, tools, filehash
Suggests: snowfall
Description: Haplin performs a genetic association analysis of
case-parent triad (trio) data with multiple markers. It can
also incorporate complete or incomplete control triads, for
instance independent control children. Estimation is based on
haplotypes, for instance SNP haplotypes, even though phase is
not known from the genetic data. Haplin estimates relative risk
(RR + conf.int.) and p-value associated with each haplotype. It
uses maximum likelihood estimation to make optimal use of data
from triads with missing genotypic data, for instance if some
SNPs has not been typed for some individuals. Haplin also
allows estimation of effects of maternal haplotypes and
parent-of-origin effects, particularly appropriate in perinatal
epidemiology. Haplin allows special models, like
X-inactivation, to be fitted on the X-chromosome.
License: GPL (>= 2)
URL: http://www.uib.no/smis/gjessing/genetics/software/haplin/
Packaged: 2013-02-06 12:55:09 UTC; hkgjess
Repository: CRAN
Date/Publication: 2013-02-06 14:41:20

Package: Haplin
Type: Package
Title: Analyzing case-parent triad and/or case-control data with SNP
haplotypes
Version: 5.2
Date: 2013-04-28
Author: Hakon K. Gjessing
Maintainer: Hakon K. Gjessing <hakon.gjessing@fhi.no>
Depends: MASS, mgcv, parallel, GenABEL, DatABEL, tools, filehash
Suggests: snowfall
Description: Haplin performs a genetic association analysis of
case-parent triad (trio) data with multiple markers. It can
also incorporate complete or incomplete control triads, for
instance independent control children. Estimation is based on
haplotypes, for instance SNP haplotypes, even though phase is
not known from the genetic data. Haplin estimates relative risk
(RR + conf.int.) and p-value associated with each haplotype. It
uses maximum likelihood estimation to make optimal use of data
from triads with missing genotypic data, for instance if some
SNPs has not been typed for some individuals. Haplin also
allows estimation of effects of maternal haplotypes and
parent-of-origin effects, particularly appropriate in perinatal
epidemiology. Haplin allows special models, like
X-inactivation, to be fitted on the X-chromosome.
License: GPL (>= 2)
URL: http://www.uib.no/smis/gjessing/genetics/software/haplin/
Packaged: 2013-04-28 10:36:34 UTC; hkgjess
NeedsCompilation: no
Repository: CRAN
Date/Publication: 2013-05-02 15:20:23